Article
Germ-line mutations in BRCA1 or BRCA2 in the normal breast are associated with altered expression of estrogen-responsive proteins and the predominance of progesterone receptor A.
Genes, chromosomes & cancer - 1 Mar 2004
Mote Patricia A, Leary Jennifer A, Avery Kelly A, Sandelin Kerstin, Chenevix-Trench Georgia, Kirk Judy A, Clarke Christine L
Abstract excerpt
The breast cancer susceptibility genes BRCA1 and BRCA2 are responsible for a large proportion of familial breast and ovarian cancer, yet little is known of how disruptions in the functions of the proteins these genes encode increased cancer risk preferentially in hormone-dependent tissue. There is no information on whether a germ-line mutation in BRCA1 or BRCA2 causes disruptions in hormone-signaling pathways in...
Topics
- Adult
- Aged
- BRCA1 Protein
- BRCA2 Protein
- Biomarkers
- Breast
- Breast Neoplasms
- Epithelial Cells
- Female
- Genes, BRCA1
- Genes, BRCA2
- Genes, Dominant
- Genetic Predisposition to Disease