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Article

Role of Ras signaling in the induction of snail by transforming growth factor-beta.

The Journal of biological chemistry - 2 Jan 2009

Horiguchi Kana, Shirakihara Takuya, Nakano Ayako, Imamura Takeshi, Miyazono Kohei, Saitoh Masao

Abstract excerpt

The epithelial-mesenchymal transition (EMT) is a crucial morphological event that occurs during the progression of epithelial tumors. EMT can be induced by transforming growth factor (TGF)-beta in some tumor cells. Here, we demonstrate the molecular mechanism whereby Snail, a key regulator of EMT, is induced by TGF-beta in tumor cells. Snail induction by TGF-beta was highly dependent on cooperation with active...

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Source

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PMID: 19010789
DOI: 10.1074/jbc.M804777200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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