Article
A non-canonical E-box within the MyoD core enhancer is necessary for circadian expression in skeletal muscle.
Nucleic acids research - 1 Apr 2012
Zhang Xiping, Patel Samir P, McCarthy John J, Rabchevsky Alexander G, Goldhamer David J, Esser Karyn A
Abstract excerpt
The myogenic differentiation 1 (MyoD) gene is a master regulator of myogenesis. We previously reported that the expression of MyoD mRNA oscillates over 24 h in skeletal muscle and that the circadian clock transcription factors, BMAL1 (brain and muscle ARNT-like 1) and CLOCK (circadian locomotor output cycles kaput), were bound to the core enhancer (CE) of the MyoD gene in vivo. In this study, we provide in vivo...
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