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Article

Investigation of the role of electrostatic charge in activation of the Escherichia coli response regulator CheY.

Journal of bacteriology - 1 Nov 2003

Smith Jenny G, Latiolais Jamie A, Guanga Gerald P, Citineni Sindhura, Silversmith Ruth E, Bourret Robert B

Abstract excerpt

In a two-component regulatory system, an important means of signal transduction in microorganisms, a sensor kinase phosphorylates a response regulator protein on an aspartyl residue, resulting in activation. The active site of the response regulator is highly charged (containing a lysine, the phosphorylatable aspartate, two additional aspartates involved in metal binding, and an Mg(2+) ion), and introduction of...

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Identifiers

PMID: 14563873
DOI: 10.1128/JB.185.21.6385-6391.2003
PMCID: PMC219398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Investigation of the role of electrostatic charge in activation of the Escherichia coli response regulator CheY.PMID 14563873Read ↗

Roles of the highly conserved aspartate and lysine residues in the response regulator of bacterial chemotaxis.Semantic proximity Read ↗

Conserved aspartate residues and phosphorylation in signal transduction by the chemotaxis protein CheY.Semantic proximity Read ↗

Role of Position K+4 in the Phosphorylation and Dephosphorylation Reaction Kinetics of the CheY Response Regulator.Semantic proximity Read ↗

Structure and catalytic mechanism of the E. coli chemotaxis phosphatase CheZ.Semantic proximity Read ↗

Genetic analysis of response regulator activation in bacterial chemotaxis suggests an intermolecular mechanism.Semantic proximity Read ↗

Proposed signal transduction role for conserved CheY residue Thr87, a member of the response regulator active-site quintet.Semantic proximity Read ↗

Synthesis and biochemical characterization of a phosphorylated analogue of the response regulator CheB.Semantic proximity Read ↗

A search for amino acid substitutions that universally activate response regulators.Semantic proximity Read ↗

Phosphorylation-dependent binding of the chemotaxis signal molecule CheY to its phosphatase, CheZ.Semantic proximity Read ↗

Interaction of CheY with the C-terminal peptide of CheZ.Semantic proximity Read ↗

Activation of CheY mutant D57N by phosphorylation at an alternative site, Ser-56.Semantic proximity Read ↗

Correlated switch binding and signaling in bacterial chemotaxis.Semantic proximity Read ↗

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