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Article

Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene.

Blood - 1 Jun 2006

Dame Christof, Kirschner Karin M, Bartz Katharina V, Wallach Thomas, Hussels Christiane S, Scholz Holger

Abstract excerpt

Molecular mechanisms for the developmental stage and tissue-specific regulation of the erythropoietin (EPO) gene are poorly understood. Recent findings indicate a role of the Wilms tumor suppressor, Wt1, in the formation of the hematopoietic system. Herein, we tested the hypothesis that Wt1 is a transcriptional regulator of the EPO gene. Binding of the transcriptionally competent Wt1(-KTS) isoform to the minimal...

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Share to Binding Sites
Share to Cell Line, Tumor
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 16467207
DOI: 10.1182/blood-2005-07-2889

Genes

EPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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