Article
Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis.
Science (New York, N.Y.) - 7 Jul 2006
Yoshida Satoshi, Kono Keiko, Lowery Drew M, Bartolini Sara, Yaffe Michael B, Ohya Yoshikazu, Pellman David
Abstract excerpt
The links between the cell cycle machinery and the cytoskeletal proteins controlling cytokinesis are poorly understood. The small guanine nucleotide triphosphate (GTP)-binding protein RhoA stimulates type II myosin contractility and formin-dependent assembly of the cytokinetic actin contractile ring. We found that budding yeast Polo-like kinase Cdc5 controls the targeting and activation of Rho1 (RhoA) at the...
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