Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification.

doi:10.1093/hmg/10.22.2593

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Article

Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification.

Human molecular genetics - 15 Oct 2001

Murdoch J N, Doudney K, Paternotte C, Copp A J, Stanier P

Abstract excerpt

Neural tube defects (NTD) are clinically important congenital malformations whose molecular mechanisms are poorly understood. The loop-tail (Lp) mutant mouse provides a model for the most severe NTD, craniorachischisis, in which the brain and spinal cord remain open. During a positional cloning approach, we have identified a mutation in a novel gene, Lpp1, in the Lp mouse, providing a strong candidate for the...

Topics

Amino Acid Sequence
Animals
Base Sequence
DNA, Complementary
Embryo, Mammalian
Exons
Female
Gene Expression Regulation, Developmental
Genes
In Situ Hybridization
Introns

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred C57BL

Mice, Inbred CBA

Molecular Sequence Data

Muridae

Mutation

Source

Open in PubMed

Identifiers

PMID: 11709546
DOI: 10.1093/hmg/10.22.2593

Genes

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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