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Article

Stability and folding of the tumour suppressor protein p16.

Journal of molecular biology - 29 Jan 1999

Tang K S, Guralnick B J, Wang W K, Fersht A R, Itzhaki L S

Abstract excerpt

The tumour suppressor p16 is a member of the INK4 family of inhibi tors of the cyclin D-dependent kinases, CDK4 and CDK6, that are involved in the key growth control pathway of the eukaryotic cell cycle. The 156 amino acid residue protein is composed of four ankyrin repeats (a helix-turn-helix motif) that stack linearly as two four-helix bundles resulting in a non-globular, elongated molecule. The thermodynamic...

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Source

Identifiers

PMID: 9917418
DOI: 10.1006/jmbi.1998.2420

Genes

CDK4
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Stability and folding of the tumour suppressor protein p16.PMID 9917418Read ↗

Sequential unfolding of ankyrin repeats in tumor suppressor p16.Semantic proximity Read ↗

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Structural consequences of tumor-derived mutations in p16INK4a probed by limited proteolysis.Semantic proximity Read ↗

Amyloid formation and depolymerization of tumor suppressor p16INK4a are regulated by a thiol-dependent redox mechanism.Semantic proximity Read ↗

Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.Semantic proximity Read ↗

Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6.Semantic proximity Read ↗

Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a.Semantic proximity Read ↗

The tumor suppressor protein p16INK4a.Semantic proximity Read ↗

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Regulation of Tumor Suppressor Gene CDKN2A and Encoded p16-INK4a Protein by Covalent ModificationsSemantic proximity Read ↗

Structure of the cyclin-dependent kinase inhibitor p19Ink4d.Semantic proximity Read ↗

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