Article
Stability and folding of the tumour suppressor protein p16.
Journal of molecular biology - 29 Jan 1999
Tang K S, Guralnick B J, Wang W K, Fersht A R, Itzhaki L S
Abstract excerpt
The tumour suppressor p16 is a member of the INK4 family of inhibi tors of the cyclin D-dependent kinases, CDK4 and CDK6, that are involved in the key growth control pathway of the eukaryotic cell cycle. The 156 amino acid residue protein is composed of four ankyrin repeats (a helix-turn-helix mo...
Topics
- Circular Dichroism
- Cyclin-Dependent Kinase Inhibitor p16
- Drug Stability
- Escherichia coli
- Humans
- In Vitro Techniques
- Kinetics
- Models, Molecular
- Mutation
- Proline
- Protein Conformation
- Protein Denaturation
- Protein Folding
- Protein Structure, Secondary
- Recombinant Proteins
- Spectrometry, Fluorescence
- Thermodynamics
- Urea