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Article

Rapid screening of 4000 individuals for germ-line variations in the BRAF gene.

Clinical chemistry - 1 Sept 2006

James Michael R, Dumeni Troy, Stark Mitchell S, Duffy David L, Montgomery Grant W, Martin Nicholas G, Hayward Nicholas K

Abstract excerpt

BACKGROUND: The BRAF gene is frequently somatically altered in malignant melanoma. A majority of variations are at the valine 600 residue leading to a V600E substitution that constitutively activates the kinase. We screened 4000 patient and control DNAs for germ-line variations at the valine 600 residue. METHODS: We developed a novel assay by adapting single-base variation assays and software for MALDI-TOF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16873291
DOI: 10.1373/clinchem.2006.070169

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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