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Article

Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana.

The Journal of biological chemistry - 26 Mar 2004

Davis Antony J, Perugini Matthew A, Smith Brian J, Stewart James D, Ilg Thomas, Hodder Anthony N, Handman Emanuela

Abstract excerpt

Leishmania parasites synthesize a range of mannose-containing glycoconjugates thought to be essential for virulence in the mammalian host and sandfly vector. A prerequisite for the synthesis of these molecules is the availability of the activated mannose donor, GDP-Man, the product of the catalys...

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PMID: 14718535
DOI: 10.1074/jbc.M312365200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14718535-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana.PMID 14718535Read ↗

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