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Open and Closed Structures of the UDP-glucose Pyrophosphorylase from Leishmania major

16 Feb 2007

Abstract excerpt

Uridine diphosphate-glucose pyrophosphorylase (UGPase) represents a ubiquitous enzyme, which catalyzes the formation of UDP-glucose, a key metabolite of the carbohydrate pathways of all organisms. In the protozoan parasite Leishmania major, which causes a broad spectrum of diseases and is transmitted to humans by sand fly vectors, UGPase represents a virulence factor because of its requirement for the synthesis...

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PMID: 17303565
DOI: 10.1074/jbc.m609984200

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