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Article

GDP-mannose pyrophosphorylase is essential in the bloodstream form of Trypanosoma brucei.

The Biochemical journal - 15 Jan 2010

Denton Helen, Fyffe Stewart, Smith Terry K

Abstract excerpt

A putative GDP-Man PP (guanidine diphosphomannose pyrophosphorylase) gene from Trypanosoma brucei (TbGDP-Man PP) was identified in the genome and subsequently cloned, sequenced and recombinantly expressed, and shown to be a catalytically active dimer. Kinetic analysis revealed a Vmax of 0.34 mumol/min per mg of protein and Km values of 67 muM and 12 muM for GTP and mannose 1-phosphate respectively. Further...

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Identifiers

PMID: 19919534
DOI: 10.1042/BJ20090896

Genes

GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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