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Article

Evidence that intracellular beta1-2 mannan is a virulence factor in Leishmania parasites.

The Journal of biological chemistry - 17 Oct 2003

Ralton Julie E, Naderer Thomas, Piraino Helena L, Bashtannyk Tanya A, Callaghan Judy M, McConville Malcolm J

Abstract excerpt

The protozoan parasite Leishmania mexicana proliferates within macrophage phagolysosomes in the mammalian host. In this study we provide evidence that a novel class of intracellular beta1-2 mannan oligosaccharides is important for parasite survival in host macrophages. Mannan (degree of polymerization 4-40) is expressed at low levels in non-pathogenic promastigote stages but constitutes 80 and 90% of the cellular...

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Identifiers

PMID: 12902334
DOI: 10.1074/jbc.M307660200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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