Article
[From gene to disease; risk factors for venous thrombosis: factor V Leiden and prothrombin 20210A].
Nederlands tijdschrift voor geneeskunde - 22 Sept 2001
Reitsma P H, van de Stolpe A
Abstract excerpt
Venous thromboembolic disease is an important clinical entity, in which both acquired and genetic risk factors play a causative role. Genetic factors which increase thrombotic risk consist of rare heterogeneous loss-of-function mutations in coagulation-inhibitory factors, such as antithrombin, protein S and C, and more common, but unique, gain-of-function mutations in coagulation factors V and II, so-called...
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