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Article

Notch promotes neural lineage entry by pluripotent embryonic stem cells.

PLoS biology - 1 May 2006

Lowell Sally, Benchoua Alexandra, Heavey Barry, Smith Austin G

Abstract excerpt

A central challenge in embryonic stem (ES) cell biology is to understand how to impose direction on primary lineage commitment. In basal culture conditions, the majority of ES cells convert asynchronously into neural cells. However, many cells resist differentiation and others adopt nonneural fates. Mosaic activation of the neural reporter Sox-green fluorescent protein suggests regulation by cell-cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16594731
DOI: 10.1371/journal.pbio.0040121
PMCID: PMC1431581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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