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Article

Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1.

Cell stem cell - 6 Mar 2009

Fuchs Sebastian, Herzog Dominik, Sumara Grzegorz, Büchmann-Møller Stine, Civenni Gianluca, Wu Xunwei, Chrostek-Grashoff Anna, Suter Ueli, Ricci Romeo, Relvas João B, Brakebusch Cord, Sommer Lukas

Abstract excerpt

The neural crest (NC) generates a variety of neural and non-neural tissues during vertebrate development. Both migratory NC cells and their target structures contain cells with stem cell features. Here we show that these populations of neural crest-derived stem cells (NCSCs) are differentially regulated by small Rho GTPases. Deletion of either Cdc42 or Rac1 in the NC results in size reduction of multiple NC...

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Source

Identifiers

PMID: 19265663
DOI: 10.1016/j.stem.2009.01.017

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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