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Article

Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Jan 2004

Zhou Cheng-Ji, Zhao Chunjie, Pleasure Samuel J

Abstract excerpt

LRP6 mutant mice have generalized defects in the Wnt/beta-catenin signaling pathway because of the crucial function of LRP6 as a Wnt signaling co-receptor (Pinson et al., 2000). We examined the hippocampal phenotype of single LRP6 mutant mice as well as LRP6/Lef1 double mutant mice. LRP6 mutants had reduced production of dentate granule neurons and abnormalities of the radial glial scaffolding in the forming...

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Source

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Identifiers

PMID: 14715945
DOI: 10.1523/JNEUROSCI.4071-03.2004
PMCID: PMC6729560

Genes

LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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