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Article

Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants.

The Journal of comparative neurology - 1 Sept 2008

Zhao Yangu, Flandin Pierre, Long Jason E, Cuesta Melissa Dela, Westphal Heiner, Rubenstein John L R

Abstract excerpt

Here we analyze the role of the Lhx6 lim-homeobox transcription factor in regulating the development of subsets of neocortical, hippocampal, and striatal interneurons. An Lhx6 loss-of-function allele, which expresses placental alkaline phosphatase (PLAP), allowed analysis of the development and fate of Lhx6-expressing interneurons in mice lacking this homeobox transcription factor. There are Lhx6+;Dlx+ and...

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Source

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Identifiers

PMID: 18613121
DOI: 10.1002/cne.21772
PMCID: PMC2547494

Genes

NPY
CXCR4
NPAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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