Article
Ghrelin and growth hormone secretagogue receptor (GHSR) genes are not commonly involved in growth or weight abnormalities in an Israeli pediatric population.
Journal of pediatric endocrinology & metabolism : JPEM - 1 Jan 2012
Hess Ora, Admoni Osnat, Khayat Morad, Elias Gadir, Almagor Tal, Shalev Stavit-Allon, Tenenbaum-Rakover Yardena
Abstract excerpt
CONTEXT AND OBJECTIVE: Ghrelin and its receptor, growth hormone secretagogue receptor (GHSR), have key roles in appetite control and growth regulation. To date, only few mutations of GHSR have been identified in children with obesity and short stature. We hypothesized that mutations in ghrelin or GHSR will result in disrupted growth and weight regulation in children. DESIGN: A total of 98 subjects (38 females and...
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