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Article

Type 2 transglutaminase differentially modulates striatal cell death in the presence of wild type or mutant huntingtin.

Journal of neurochemistry - 1 Jul 2007

Ruan Qingmin, Quintanilla Rodrigo A, Johnson Gail V W

Abstract excerpt

Huntington's disease (HD), which is caused by an expanded polyglutamine tract in huntingtin (htt), is characterized by extensive loss of striatal neurons. The dysregulation of type 2 transglutaminase (TG2) has been proposed to contribute to the pathogenesis in HD as TG2 is up-regulated in HD brain and knocking out TG2 in mouse models of HD ameliorates the disease process. To understand the role of TG2 in the...

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Identifiers

PMID: 17403029
DOI: 10.1111/j.1471-4159.2007.04491.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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