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Article

Truncating the i-leader open reading frame enhances release of human adenovirus type 5 in glioma cells.

Virology journal - 11 Apr 2011

van den Hengel Sanne K, de Vrij Jeroen, Uil Taco G, Lamfers Martine L, Sillevis Smitt Peter Ae, Hoeben Rob C

Abstract excerpt

BACKGROUND: The survival of glioma patients with the current treatments is poor. Early clinical trails with replicating adenoviruses demonstrated the feasibility and safety of the use of adenoviruses as oncolytic agents. Antitumor efficacy has been moderate due to inefficient virus replication and spread. Previous studies have shown that truncation of the adenovirus i-leader open reading frame enhanced cytopathic...

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Identifiers

PMID: 21477385
DOI: 10.1186/1743-422X-8-162
PMCID: PMC3090740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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