Article
Ethnic differences in cytotoxic T lymphocyte associated antigen 4 genotype associations with systemic sclerosis.
The Journal of rheumatology - 1 Jan 2004
Hudson Lori L, Silver Richard M, Pandey Janardan P
Abstract excerpt
OBJECTIVE: To determine the role of cytotoxic T lymphocyte associated antigen 4 (CTLA-4) genetic polymorphisms in susceptibility to systemic sclerosis (SSc, scleroderma). METHODS: The study population consisted of 293 African American and Caucasian patients with SSc and matched controls. Subjects were genotyped for allelic determinants at 4 polymorphic sites: 3 in the promoter region (positions -318, -1661,...
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