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Article

Long-term hippocampal glutamate synapse and astrocyte dysfunctions underlying the altered phenotype induced by adolescent THC treatment in male rats.

Pharmacological research - 1 Sept 2016

Zamberletti Erica, Gabaglio Marina, Grilli Massimo, Prini Pamela, Catanese Alberto, Pittaluga Anna, Marchi Mario, Rubino Tiziana, Parolaro Daniela

Abstract excerpt

Cannabis use has been frequently associated with sex-dependent effects on brain and behavior. We previously demonstrated that adult female rats exposed to delta-9-tetrahydrocannabinol (THC) during adolescence develop long-term alterations in cognitive performances and emotional reactivity, whereas preliminary evidence suggests the presence of a different phenotype in male rats. To thoroughly depict the behavioral...

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Identifiers

PMID: 27422357
DOI: 10.1016/j.phrs.2016.07.008

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GFAP
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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