Article
Achondroplasia: pathogenesis and implications for future treatment.
Current opinion in pediatrics - 1 Aug 2010
Laederich Melanie B, Horton William A
Abstract excerpt
PURPOSE OF REVIEW: Although the genetic defect underlying achondroplasia has been known for over a decade, no effective therapies to stimulate bone growth have emerged. Here we review the recent literature and summarize the molecular mechanisms underlying disease pathology and examine their potential as therapeutic targets. Currently used preclinical models are discussed in the context of recent advances with a...
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