Article
Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells.
EBioMedicine - 1 Jan 2018
Kamei Shunsuke, Fujikawa Haruka, Nohara Hirofumi, Ueno-Shuto Keiko, Maruta Kasumi, Nakashima Ryunosuke, Kawakami Taisei, Matsumoto Chizuru, Sakaguchi Yuki, Ono Tomomi, Suico Mary Ann, Boucher Richard C, Gruenert Dieter C, Takeo Toru, Nakagata Naomi, Li Jian-Dong, Kai Hirofumi, Shuto Tsuyoshi
Abstract excerpt
Airway mucus hyperproduction and fluid imbalance are important hallmarks of cystic fibrosis (CF), the most common life-shortening genetic disorder in Caucasians. Dysregulated expression and/or function of airway ion transporters, including cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC), have been implicated as causes of CF-associated mucus hypersecretory phenotype....
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