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Article

The preferred pathway of glycosaminoglycan-accelerated inactivation of thrombin by heparin cofactor II.

The Journal of biological chemistry - 12 Mar 2004

Verhamme Ingrid M, Bock Paul E, Jackson Craig M

Abstract excerpt

Thrombin (T) inactivation by the serpin, heparin cofactor II (HCII), is accelerated by the glycosaminoglycans (GAGs) dermatan sulfate (DS) and heparin (H). Equilibrium binding and thrombin inactivation kinetics at pH 7.8 and ionic strength (I) 0.125 m demonstrated that DS and heparin bound much tighter to thrombin (K(T(DS)) 1-5.8 microm; K(T(H)) 0.02-0.2 microm) than to HCII (K(HCII(DS)) 236-291 microm;...

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Identifiers

PMID: 14701814
DOI: 10.1074/jbc.M313962200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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