Inhibition of dysthrombins Quick I and II by heparin cofactor II and antithrombin.

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Article

Inhibition of dysthrombins Quick I and II by heparin cofactor II and antithrombin.

The Journal of biological chemistry - 15 Feb 1993

Phillips J E, Shirk R A, Whinna H C, Henriksen R A, Church F C

Abstract excerpt

Heparin cofactor II and antithrombin are plasma serine proteinase inhibitors whose ability to inhibit alpha-thrombin is accelerated by glycosaminoglycans. Dysfunctional thrombin mutants Quick I (Arg67-->Cys) and Quick II (Gly226-->Val) were used to further compare heparin cofactor II and antithrombin interactions. Quick I, Quick II, and alpha-thrombin were eluted at the same salt concentration from...

Topics

Amino Acid Sequence
Antithrombins
Chromatography, Affinity
Heparin
Heparin Cofactor II
Humans
Kinetics
Models, Molecular
Mutation
Protein Conformation
Protein Structure, Secondary
Thrombin

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Open in PubMed

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PMID: 8429008

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