Article
Fucosylated chondroitin sulfate inhibits plasma thrombin generation via targeting of the factor IXa heparin-binding exosite.
Blood - 1 Oct 2009
Buyue Yang, Sheehan John P
Abstract excerpt
Depolymerized holothurian glycosaminoglycan (DHG) is a fucosylated chondroitin sulfate with antithrombin-independent antithrombotic properties. Heparin cofactor II (HCII)-dependent and -independent mechanisms for DHG inhibition of plasma thrombin generation were evaluated. When thrombin generation was initiated with 0.2 pM tissue factor (TF), the half maximal effective concentration (EC(50)) for DHG inhibition...
Topics
- Binding Sites
- Blotting, Western
- Chondroitin Sulfates
- Cysteine Endopeptidases
- Factor IXa
- Factor VIIIa
- Humans
- Mutation
- Neoplasm Proteins
- Serpins
- Thrombin
- Thromboplastin