Article
[An overview of research on p53 tumor suppressor gene].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Dec 1997
Yokozaki H, Tahara E
Abstract excerpt
The concept of tumor suppressor gene introduced in the last decade has provided an enormous understanding of the mechanism of human carcinogenesis with the intensive study of p53 during the 1990's. The product of p53 tumor suppressor gene is a transcription factor which recognizes and binds to a specific DNA consensus sequence existing in the promoter region of p53 responsive genes. The main physiological...
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