Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Sperm Do Not Bind to Rat Zonae Pellucidae Despite the Presence of Four Homologous Glycoproteins

28 Jan 2005

Abstract excerpt

The specificity of sperm-egg recognition in mammals is mediated primarily by the zona pellucida surrounding ovulated eggs. Mouse sperm are quite promiscuous and bind to human eggs, but human spermatozoa will not bind to mouse eggs. The mouse zona pellucida contains three glycoproteins, ZP1, ZP2, and ZP3, which are conserved in rat and human. The recent observation that human zonae pellucidae contain a fourth...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Genetics and Reproduction
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15677449
DOI: 10.1074/jbc.m413569200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Sperm Do Not Bind to Rat Zonae Pellucidae Despite the Presence of Four Homologous GlycoproteinsPMID 15677449Read ↗

Reassessing the molecular biology of sperm–egg recognition with mouse geneticsSemantic proximity Read ↗

Murine and human zona pellucida 3 derived from mouse eggs express identical O-glycansSemantic proximity Read ↗

Insights into the molecular basis of sperm–egg recognition in mammalsSemantic proximity Read ↗

Human sperm bind to the N-terminal domain of ZP2 in humanized zonae pellucidae in transgenic miceSemantic proximity Read ↗

Human ZP3 restores fertility in <i>Zp3</i> null mice without affecting order-specific sperm bindingSemantic proximity Read ↗

A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humansSemantic proximity Read ↗

The molecular basis of gamete recognition in mice and humansSemantic proximity Read ↗

New Insights into the Mammalian Egg Zona PellucidaSemantic proximity Read ↗

Zona pellucida glycoprotein ZP3 and fertilization in mammalsSemantic proximity Read ↗

Molecular Models for Murine Sperm-Egg BindingSemantic proximity Read ↗

Four zona pellucida glycoproteins are expressed in the humanSemantic proximity Read ↗

Fertilization in mouse does not require terminal galactose or N-acetylglucosamine on the zona pellucida glycansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.