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Article

Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.

Human molecular genetics - 15 Jan 2004

Li Na, Nakamura Kazuhiro, Jiang Yi, Tsurui Hiromichi, Matsuoka Shuji, Abe Masaaki, Ohtsuji Mareki, Nishimura Hiroyuki, Kato Kiyoshi, Kawai Takako, Atsumi Tatsuya, Koike Takao, Shirai Toshikazu, Ueno Hiroo, Hirose Sachiko

Abstract excerpt

Systemic lupus erythematosus (SLE), a complex multigenic disease, is a typical antibody-mediated autoimmune disease characterized by production of autoantibodies against a variety of autoantigens and immune complex-type tissue inflammation, most prominently in the kidney. Evidence suggests that genetic factors predisposing to aberrant proliferation/maturation of self-reactive B cells initiate and propagate the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14695357
DOI: 10.1093/hmg/ddh020

Genes

LTK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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