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Article

Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.

The American journal of pathology - 1 Jan 2004

Klein Ronald L, Lin Wen-Lang, Dickson Dennis W, Lewis Jada, Hutton Michael, Duff Karen, Meyer Edwin M, King Michael A

Abstract excerpt

Neurofibrillary pathology was produced in the brains of adult rats after localized gene transfer of human tau carrying the P301L mutation, which is associated with frontotemporal dementia with parkinsonism. Within 1 month of in situ transfection of the basal forebrain region of normal rats, tau-i...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14695347
DOI: 10.1016/S0002-9440(10)63124-0
PMCID: PMC1602230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14695347-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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