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Somatic mutations of KIT in familial testicular germ cell tumours

18 May 2004

Abstract excerpt

Somatic mutations of the KIT gene have been reported in mast cell diseases and gastrointestinal stromal tumours. Recently, they have also been found in mediastinal and testicular germ cell tumours (TGCTs), particularly in cases with bilateral disease. We screened the KIT coding sequence (except exon 1) for germline mutations in 240 pedigrees with two or more cases of TGCT. No germline mutations were found. Exons...

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PMID: 15150569
DOI: 10.1038/sj.bjc.6601880

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