Article
Primary mediastinal seminomas: evidence of single and multiple KIT mutations.
Laboratory investigation; a journal of technical methods and pathology - 1 Oct 2002
Przygodzki Ronald M, Hubbs Alan E, Zhao Feng-Qi, O'Leary Timothy J
Abstract excerpt
Primary mediastinal seminomas (MS) are rare tumors that are histologically similar to their testicular counterparts. Reports document KIT mutations in gastrointestinal stromal tumors, mastocytosis, and germ cell tumors. Although rare exon 17 mutations have been reported in gonadal seminomas, their mediastinal counterparts have not been studied. To determine whether primary MS harbor KIT mutations, eight...
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