Article
Identification of major quantitative trait loci controlling body weight variation in ob/ob mice.
Diabetes - 1 Jan 2004
Stoehr Jonathan P, Byers Jessica E, Clee Susanne M, Lan Hong, Boronenkov Igor V, Schueler Kathryn L, Yandell Brian S, Attie Alan D
Abstract excerpt
The adipocyte hormone leptin constitutes an important component of the regulation of energy homeostasis; leptin-deficient animals, such as obese mice, are strikingly overweight. The seemingly uninhibited weight gain in obese mice belies the fact that control of energy homeostasis remains under precise, heritably modifiable control. Herein, we report large, heritable differences in body weight and food intake...
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