Article
Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis.
Cell metabolism - 1 Nov 2022
Zhang Zhao, Jiang Yiao, Su Lijing, Ludwig Sara, Zhang Xuechun, Tang Miao, Li Xiaohong, Anderton Priscilla, Zhan Xiaoming, Choi Mihwa, Russell Jamie, Bu Chun-Hui, Lyon Stephen, Xu Darui, Hildebrand Sara, Scott Lindsay, Quan Jiexia, Simpson Rochelle, Sun Qihua, Qin Baifang, Collie Tiffany, Tadesse Meron, Moresco Eva Marie Y, Beutler Bruce
Abstract excerpt
Using random germline mutagenesis in mice, we identified a viable hypomorphic allele (boh) of the transcription-factor-encoding gene Ovol2 that resulted in obesity, which initially developed with normal food intake and physical activity but decreased energy expenditure. Fat weight was dramatically increased, while lean weight was reduced in 12-week-old boh homozygous mice, culminating by 24 weeks in massive...
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