Article
An interval of the obesity QTL Nob3.38 within a QTL hotspot on chromosome 1 modulates behavioral phenotypes.
PloS one - 1 Jan 2013
Vogel Heike, Montag Dirk, Kanzleiter Timo, Jonas Wenke, Matzke Daniela, Scherneck Stephan, Chadt Alexandra, Töle Jonas, Kluge Reinhart, Joost Hans-Georg, Schürmann Annette
Abstract excerpt
A region on mouse distal chromosome 1 (Chr. 1) that is highly enriched in quantitative trait loci (QTLs) controlling neural and behavioral phenotypes overlaps with the peak region of a major obesity QTL (Nob3.38), which we identified in an intercross of New Zealand Obese (NZO) mice with C57BL/6J (B6). By positional cloning we recently identified a microdeletion within this locus causing the disruption of Ifi202b...
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