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Article

Distinguishing covariation from causation in diabetes: a lesson from the protein disulfide isomerase mRNA abundance trait.

Diabetes - 1 Jan 2004

Lan Hong, Rabaglia Mary E, Schueler Kathryn L, Mata Christine, Yandell Brian S, Attie Alan D

Abstract excerpt

Protein disulfide isomerase (Pdi) is reported to be an insulin-regulated gene whose expression level is increased in the livers of rats with streptozotocin-induced diabetes. We found that Pdi mRNA is approximately 20-fold more abundant in the diabetes-susceptible BTBR mouse strain relative to the diabetes-resistant C56BL/6 (B6) strain. A genetic analysis was carried out to determine whether there is a causal...

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Identifiers

PMID: 14693722
DOI: 10.2337/diabetes.53.1.240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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