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Article

Associations between ALDH Genetic Variants, Alcohol Consumption, and the Risk of Nasopharyngeal Carcinoma in an East Asian Population.

Genes - 29 Sept 2021

Liao Wen-Ling, Chan Fu-Chun, Chang Kai-Ping, Chang Ya-Wen, Chen Che-Hong, Su Wen-Hui, Chang Hen-Hong

Abstract excerpt

Nasopharyngeal carcinoma (NPC) and alcohol flush syndrome are thought to be strongly influenced by genetic factors and are highly prevalent amongst East Asians. Diminished activity of aldehyde dehydrogenase (ALDH), a major enzyme in the alcohol-metabolizing pathway, causes the flushing syndrome associated with alcoholic consumption. The genetic effect of ALDH isoforms on NPC is unknown. We therefore investigated...

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Identifiers

PMID: 34680942
DOI: 10.3390/genes12101547
PMCID: PMC8535421

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