Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells.

PLoS biology - 1 Dec 2003

Kunwar Prabhat S, Starz-Gaiano Michelle, Bainton Roland J, Heberlein Ulrike, Lehmann Ruth

Abstract excerpt

In most organisms, germ cells are formed distant from the somatic part of the gonad and thus have to migrate along and through a variety of tissues to reach the gonad. Transepithelial migration through the posterior midgut (PMG) is the first active step during Drosophila germ cell migration. Here we report the identification of a novel G protein-coupled receptor (GPCR), Tre1, that is essential for this migration...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to rho GTP-Binding Proteins
Share to Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to Epithelium

Share to Germ Cells

Share to Leukocytes

Share to Receptors, Chemokine

Share to Receptors, G-Protein-Coupled

Source

Open in PubMed Open full text

Identifiers

PMID: 14691551
DOI: 10.1371/journal.pbio.0000080
PMCID: PMC300690

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells.PMID 14691551Read ↗

Tre1 GPCR initiates germ cell transepithelial migration by regulating Drosophila melanogaster E-cadherin.Semantic proximity Read ↗

Domain-specific control of germ cell polarity and migration by multifunction Tre1 GPCR.Semantic proximity Read ↗

A Novel Gene Controlling the Timing of Courtship Initiation in Drosophila melanogaster.Semantic proximity Read ↗

A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor.Semantic proximity Read ↗

Caenorhabditis elegans teneurin, ten-1, is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1.Semantic proximity Read ↗

Identification of genes controlling germ cell migration and embryonic gonad formation in Drosophila.Semantic proximity Read ↗

A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway.Semantic proximity Read ↗

Sex Determination in Nematode Germ CellsSemantic proximity Read ↗

Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signalingSemantic proximity Read ↗

Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration.Semantic proximity Read ↗

Mouse primordial germ cells lacking β1 integrins enter the germline but fail to migrate normally to the gonadsSemantic proximity Read ↗

The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survivalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.