Article
Absence of mutations of the BRAF gene and constitutive activation of extracellular-regulated kinase in malignant melanomas of the uvea.
Laboratory investigation; a journal of technical methods and pathology - 1 Dec 2003
Weber Anette, Hengge Ulrich R, Urbanik Doris, Markwart Annett, Mirmohammadsaegh Alireza, Reichel Martin B, Wittekind Christian, Wiedemann Peter, Tannapfel Andrea
Abstract excerpt
The v-raf murine sarcoma viral homolog B1 (BRAF) gene, one of the human isoforms of RAF, is activated by Ras, leading to cooperative effects in cells responsive to growth factor signals. Recently, somatic missense mutations of the BRAF gene have been detected in more than 66% of malignant melanomas of the skin. We analyzed 42 malignant melanomas of the uvea, 3 corresponding liver metastases, and 10 cutaneous...
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