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Article

Lack of BRAF mutations in uveal melanoma.

Cancer research - 15 Sept 2003

Rimoldi Donata, Salvi Suzanne, Liénard Danielle, Lejeune Ferdy J, Speiser Daniel, Zografos Leonidas, Cerottini Jean-Charles

Abstract excerpt

RAF proteins are serine/threonine kinases that mediate cellular responses to growth signals by activating the mitogen-activated protein kinase pathway. Mutations in the BRAF gene causing a V599E amino acid substitution that enhance the kinase activity have been described in >60% of cutaneous mela...

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Source

Identifiers

PMID: 14522889

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14522889-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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