Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest.

The Journal of cell biology - 22 Dec 2003

Tunquist Brian J, Eyers Patrick A, Chen Lin G, Lewellyn Andrea L, Maller James L

Abstract excerpt

In cells containing disrupted spindles, the spindle assembly checkpoint arrests the cell cycle in metaphase. The budding uninhibited by benzimidazole (Bub) 1, mitotic arrest-deficient (Mad) 1, and Mad2 proteins promote this checkpoint through sustained inhibition of the anaphase-promoting complex/cyclosome. Vertebrate oocytes undergoing meiotic maturation arrest in metaphase of meiosis II due to a cytoplasmic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Calcium-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, cdc

Share to Mad2 Proteins

Share to Meiosis

Share to Metaphase

Share to Oogenesis

Share to Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 14691134
DOI: 10.1083/jcb.200306153
PMCID: PMC2173727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest.PMID 14691134Read ↗

The spindle checkpoint kinase bub1 and cyclin e/cdk2 both contribute to the establishment of meiotic metaphase arrest by cytostatic factor.Semantic proximity Read ↗

The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes.Semantic proximity Read ↗

Mos/mitogen-activated protein kinase can induce early meiotic phenotypes in the absence of maturation-promoting factor: a novel system for analyzing spindle formation during meiosis I.Semantic proximity Read ↗

Changing Mad2 Levels Affects Chromosome Segregation and Spindle Assembly Checkpoint Control in Female Mouse Meiosis ISemantic proximity Read ↗

Meiotic spindle stability depends on MAPK-interacting and spindle-stabilizing protein (MISS), a new MAPK substrate.Semantic proximity Read ↗

Mechanical basis of meiotic metaphase arrest.Semantic proximity Read ↗

Anastral meiotic spindle morphogenesis: role of the non-claret disjunctional kinesin-like protein.Semantic proximity Read ↗

Meiotic metaphase arrest in animal oocytes: its mechanisms and biological significanceSemantic proximity Read ↗

Cell cycle checkpoints: Arresting progress in mitosisSemantic proximity Read ↗

A mitotic role for Mad1 beyond the spindle checkpoint.Semantic proximity Read ↗

The Bub2-dependent mitotic pathway in yeast acts every cell cycle and regulates cytokinesis.Semantic proximity Read ↗

A microtubule-destabilizing kinesin motor regulates spindle length and anchoring in oocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.