Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Meiotic spindle stability depends on MAPK-interacting and spindle-stabilizing protein (MISS), a new MAPK substrate.

The Journal of cell biology - 13 May 2002

Lefebvre Christophe, Terret M Emilie, Djiane Alexandre, Rassinier Pascale, Maro Bernard, Verlhac Marie-Hélène

Abstract excerpt

Vertebrate oocytes arrest in the second metaphase of meiosis (metaphase II [MII]) by an activity called cytostatic factor (CSF), with aligned chromosomes and stable spindles. Segregation of chromosomes occurs after fertilization. The Mos/.../MAPK (mitogen-activated protein kinases) pathway mediates this MII arrest. Using a two-hybrid screen, we identified a new MAPK partner from a mouse oocyte cDNA library. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Oocytes
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, myc

Share to MAP Kinase Signaling System

Share to Meiosis

Share to Mitosis

Share to Oligonucleotide Probes

Share to Spindle Apparatus

Source

Open in PubMed Open full text

Identifiers

PMID: 12011110
DOI: 10.1083/jcb.200202052
PMCID: PMC2173866

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Meiotic spindle stability depends on MAPK-interacting and spindle-stabilizing protein (MISS), a new MAPK substrate.PMID 12011110Read ↗

DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytesSemantic proximity Read ↗

Live imaging RNAi screen reveals genes essential for meiosis in mammalian oocytes.Semantic proximity Read ↗

The spindle checkpoint kinase bub1 and cyclin e/cdk2 both contribute to the establishment of meiotic metaphase arrest by cytostatic factor.Semantic proximity Read ↗

Meiotic spindle formation in mammalian oocytes: implications for human infertility†Semantic proximity Read ↗

Mos/mitogen-activated protein kinase can induce early meiotic phenotypes in the absence of maturation-promoting factor: a novel system for analyzing spindle formation during meiosis I.Semantic proximity Read ↗

Association of Maternal mRNA and Phosphorylated EIF4EBP1 Variants With the Spindle in Mouse Oocytes: Localized Translational Control Supporting Female Meiosis in MammalsSemantic proximity Read ↗

Recent Insights into Spindle Function in Mammalian Oocytes and Early Embryos1Semantic proximity Read ↗

Ste20‐like kinase activity promotes meiotic resumption and spindle microtubule stability in mouse oocytesSemantic proximity Read ↗

Meiotic abnormalities of c-mos knockout mouse oocytes: activation after first meiosis or entrance into third meiotic metaphase.Semantic proximity Read ↗

Oocyte Spindle Proteomics Analysis Leading to Rescue of Chromosome Congression Defects in Cloned EmbryosSemantic proximity Read ↗

mini spindles: A gene encoding a conserved microtubule-associated protein required for the integrity of the mitotic spindle in Drosophila.Semantic proximity Read ↗

Echinoderm Microtubule Associated Protein Like 1 Is Indispensable for Oocyte Spindle Assembly and Meiotic Progression in MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.