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Article

The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes.

The Journal of cell biology - 20 Dec 2004

Tsurumi Chizuko, Hoffmann Steffen, Geley Stephan, Graeser Ralph, Polanski Zbigniew

Abstract excerpt

In Xenopus oocytes, the spindle assembly checkpoint (SAC) kinase Bub1 is required for cytostatic factor (CSF)-induced metaphase arrest in meiosis II. To investigate whether matured mouse oocytes are kept in metaphase by a SAC-mediated inhibition of the anaphase-promoting complex/cyclosome (APC/C) complex, we injected a dominant-negative Bub1 mutant (Bub1dn) into mouse oocytes undergoing meiosis in vitro. Passage...

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Identifiers

PMID: 15611331
DOI: 10.1083/jcb.200405165
PMCID: PMC2172623

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes.PMID 15611331Read ↗

The spindle checkpoint kinase bub1 and cyclin e/cdk2 both contribute to the establishment of meiotic metaphase arrest by cytostatic factor.Semantic proximity Read ↗

Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest.Semantic proximity Read ↗

Changing Mad2 Levels Affects Chromosome Segregation and Spindle Assembly Checkpoint Control in Female Mouse Meiosis ISemantic proximity Read ↗

Mad2 is dispensable for accurate chromosome segregation but becomes essential when oocytes are subjected to environmental stressSemantic proximity Read ↗

CDC6 requirement for spindle formation during maturation of mouse oocytes.Semantic proximity Read ↗

Cyclin B3 promotes anaphase I onset in oocyte meiosisSemantic proximity Read ↗

Spindle assembly checkpoint regulates mitotic cell cycle progression during preimplantation embryo development.Semantic proximity Read ↗

Cyclin B3 promotes APC/C activation and anaphase I onset in oocyte meiosisSemantic proximity Read ↗

Smc1β is required for activation of SAC during mouse oocyte meiosisSemantic proximity Read ↗

DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpointSemantic proximity Read ↗

Evidence That a Defective Spindle Assembly Checkpoint Is Not the Primary Cause of Maternal Age-Associated Aneuploidy in Mouse Eggs1Semantic proximity Read ↗

BRCA1 Is Required for Meiotic Spindle Assembly and Spindle Assembly Checkpoint Activation in Mouse Oocytes1Semantic proximity Read ↗

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