Article
The novel exon 11 mutation of BRCA1 gene in a high-risk family.
Neoplasma - 1 Jan 2003
Cierniková S, Tomka M, Sedláková O, Reinerová M, Stevurková V, Kovác M, Cente M, Ilenciková D, Bella V, Zajac V
Abstract excerpt
Germline mutations in the BRCA1 and BRCA2 genes are required for the initiation of the development of hereditary forms of breast and ovarian cancer, which represent 10-15% of all cases. The course of the disease varies from case to case that can be due even to the possibility of multiple genetic changes including inactivation of other tumor suppressor genes--TP53 and APC genes or activation of oncogenes,...
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