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A novel frequent BRCA1 allele in Chinese patients with breast cancer.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban - 1 Jan 2006

Zhou Dongxian, Xiong Wen, Xu Hongxan, Shao Chaopeng

Abstract excerpt

The whole length of exon 11 of BRCA1 was sequenced (total 3427 bp) in 59 patients and 10 healthy female blood donors. To allow a rapid determination of the different BRCA1 alleles, a sequence-specific primer PCR method (PCR-SSP) was established and was applied to 57 additional female donors. Finally, the full-length coding region of BRCA1 was analyzed through reversed-transcriptase PCR (RT-PCR) and cDNA...

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Identifiers

PMID: 17219973
DOI: 10.1007/s11596-006-0525-4

Genes

BRCA1

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