Article
Implication of BRCA1 gene in breast cancer.
Indian journal of experimental biology - 1 May 2001
Kachhap S K, Ghosh S N
Abstract excerpt
Breast cancer susceptibility gene (BRCA1) is known to be responsible for hereditary breast and ovarian cancer. This gene is highly penetrant conferring a risk for 0.92 by the age of 70. Germline mutation in this gene leads to susceptibility to breast and ovarian cancer, with a genotype phenotype correlation. Frequency of mutations of this gene in normal population of breast cancer is low suggesting that the...
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