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Article

CFTR, SPINK1, PRSS1, and CTRC mutations are not associated with pancreatic cancer in German patients.

Pancreas - 1 Oct 2014

Schubert Stephanie, Traub Frank, Brakensiek Kai, von Kopylow Kathrein, Marohn Britta, Maelzer Madeleine, Gaedcke Jochen, Kreipe Hans, Stuhrmann Manfred

Abstract excerpt

OBJECTIVE: Mutations in the cationic trypsinogen (PRSS1), cystic fibrosis transmembrane conductance regulator (CFTR), serine protease inhibitor Kazal type 1 (SPINK1), and chymotrypsin C (CTRC) genes are associated with an elevated risk for chronic pancreatitis, which is a known risk factor for pa...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25003218
DOI: 10.1097/MPA.0000000000000166

Genes

CFTR
CTRC
PRSS1
SPINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25003218-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CFTR, SPINK1, PRSS1, and CTRC mutations are not associated with pancreatic cancer in German patients.PMID 25003218Read ↗

Analysis of CFTR, SPINK1, PRSS1 and AAT mutations in children with acute or chronic pancreatitis.Semantic proximity Read ↗

Mutation analysis of PRSS1, SPINK1 and CFTR gene in patients with alcoholic and idiopathic chronic pancreatitis: A single center study.Semantic proximity Read ↗

Clinical and Morphological Characteristics of Sporadic Genetically Determined Pancreatitis as Compared to Idiopathic Pancreatitis: Higher Risk of Pancreatic Cancer in CFTR VariantsSemantic proximity Read ↗

Identification of CFTR, PRSS1, and SPINK1 mutations in 381 patients with pancreatitis.Semantic proximity Read ↗

Complete cystic fibrosis transmembrane conductance regulator gene sequencing in patients with idiopathic chronic pancreatitis and controls.Semantic proximity Read ↗

CFTR, PRSS1 and SPINK1 mutations in the development of pancreatitis in Brazilian patients.Semantic proximity Read ↗

PRSS1 intron mutations in patients with pancreatic cancer and chronic pancreatitis.Semantic proximity Read ↗

Pancreatitis-Associated Genes and Pancreatic Cancer Risk: A Systematic Review and Meta-analysis.Semantic proximity Read ↗

CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?Semantic proximity Read ↗

Hereditary Pancreatitis Related to SPINK-1 Mutation. Is There an Increased Risk of Developing Pancreatic Cancer?Semantic proximity Read ↗

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