Article
Resting B cells from New Zealand Black mice demonstrate a defect in apoptosis induction following surface IgM ligation.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1996
Kozono Y, Kotzin B L, Holers V M
Abstract excerpt
New Zealand Black (NZB) mice spontaneously develop autoimmune disease, usually characterized by an autoimmune hemolytic anemia, and NZB genes are essential for a severe systemic lupus-like disease in (NZB x NZW)F1 mice. We have found that resting B cells from NZB mice demonstrate a pronounced def...
Topics
- Animals
- Antibodies, Anti-Idiotypic
- Apoptosis
- Autoimmune Diseases
- B-Lymphocytes
- Fas Ligand Protein
- Female
- Immunoglobulin M
- Interphase
- Ligands
- Male
- Membrane Glycoproteins
- Mice
- Mice, Inbred AKR
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Inbred NZB